Predrag Kukic

and Dr. Nathan Baker Washington University, St. Louis, Missouri

Research projects (supported by IRCSET funding)

• Electric field propagation in lysozyme studied by NMR spectroscopy
• pH-dependent conformational changes in enzymes measured by NMR chemical shifts
• Electric field propagation in plastocyanin from A. variabilis, plastocyanin from P.laminosum, bovine acyl-coenzyme A binding protein, human glutaredoxin 1, β-(1,4)-glycosidase Cex from Cellulomonas fimi and a hyperstable form of Straphylococcal nuclease
• Salt and pH effects on ionization equilibria in proteins
• Ionization equilibria in protein tyrosine phosphatases

Publications

Predrag Kukic, Damien Farrell, Chresten R. Søndergaard, Una Bjarnadottir, John Bradley, Gianluca Pollastri, Jens Erik Nielsen
Improving the analysis of NMR spectra tracking pH-induced conformational changes: Removing artefacts of the electric field on the NMR chemical shift.
Proteins: Structure, Function, and Bioinformatics, March 2010, 78(4), 971-984

Predrag Kukic, Jens Erik Nielsen
Electrostatics in proteins and protein–ligand complexes.
Future Medicinal Chemistry, April 2010, 2(4), 647-666

Conferences (oral presentation)

Protein Science Young Investigator Travel Grant/ Finn Wold Travel Award
The 25the Anniversary Symposium of The Protein Science, July 2011, Boston, USA
Title: The active site cleft in HEWL has a low dielectric constant

PhD symposium: Computational Biology and Innovation, Dublin, December 2010, Ireland
Title: Electric fields in an enzyme active site

Conferences (poster presentation)

Celebrate the 50th Anniversary of the Determination of the Structure of Myoglobin. VIII European Symposium of The Protein Society Zurich, Switzerland, June 14-18, 2008

FEBS Journal Youth Travel Grant
21st IUBMB International Congress and 12th FAOBMB Congress of Biochemistry and Molecular Biology, Shanghai, August 2-7, 2009

Contact information